Arthur Cho

A Short Biography:

Dr. Cho's laboratory utilizes chemical approaches to conduct research in biotransformation reactions and their role in the actions for foreign compounds such as drugs and environmental chemical species. The biotransformation studies investigate mechanisms of oxidation of foreign compounds by cytochrome P450, an enzyme system capable of oxidizing the carbon atom of a variety of functional groups including ethers, olefins and amines. Since many of the reaction products of this system are pharmacologically or toxicologically active, their formation is important in understanding drug action. Currently the laboratory is engaged in air pollution toxicology, having developed chemical approaches to the understanding of adverse effects associate with air pollutants. In this work, the chemical basis for pro-oxidant and electrophilic properties of air pollutants has been studied and its relationship to the inflammatory and adaptive responses associated with these pollutants determined. This approach is now being applied to a study examining the relationship between air pollutants and effects on transgenic animals with a propensity to develop a Parkinson-like syndrome, characterized by movement deficits and neurochemical changes.

Work Titles
UCLA Professor Emeritus, Environmental Health Sciences Professor Emeritus, Molecular & Medical Pharmacology
Education:
Degrees:
Ph.D., UCLA
M.S., Oregon State College
B.S., University of California, Berkeley

Contact Information:

Work Email Address:

acho@mednet.ucla.edu


Website:

Pubmed Publications

Fax Number:

310.206.9903

Work Phone Number:

310.825.6567

Mailing Address:

UCLA Molecular & Medical Pharmacology/ Environmental Health Sciences
BOX 951772, 21-297 CHS
Los Angeles, CA 90095


Publications:

A selected list of publications:

Gysel Nicholas, Dixit Poornima, Schmitz Debra A, Engling Guenter, Cho Arthur K, Cocker David R, Karavalakis Georgios   Chemical speciation, including polycyclic aromatic hydrocarbons (PAHs), and toxicity of particles emitted from meat cooking operations The Science of the total environment, 2018; 633: 1429-1436.
Cho Arthur K   A Chemical Perspective of Pharmacology and Toxicology Annual review of pharmacology and toxicology, 2018; 58(1): 1-16.
Karavalakis Georgios, Gysel Nicholas, Schmitz Debra A, Cho Arthur K, Sioutas Constantinos, Schauer James J, Cocker David R, Durbin Thomas D   Impact of biodiesel on regulated and unregulated emissions, and redox and proinflammatory properties of PM emitted from heavy-duty vehicles The Science of the total environment, 2017; 584-585(5): 1230-1238.
Miotto Karen, Cho Arthur K, Khalil Mohamed A, Blanco Kirsten, Sasaki Jun D, Rawson Richard   Trends in Tramadol: Pharmacology, Metabolism, and Misuse Anesthesia and analgesia, 2017; 124(1): 44-51.
Eiguren-Fernandez Arantza, Di Stefano Emma, Schmitz Debra A, Guarieiro Aline Lefol Nani, Salinas Erika M, Nasser Elina, Froines John R, Cho Arthur K   Chemical reactivities of ambient air samples in three Southern California communities Journal of the Air & Waste Management Association (1995), 2015; 65(3): 270-7.
Shinkai Yasuhiro, Nakajima Syun, Eiguren-Fernandez Arantza, Di Stefano Emma, Schmitz Debra A, Froines John R, Cho Arthur K, Kumagai Yoshito   Ambient vapor samples activate the Nrf2-ARE pathway in human bronchial epithelial BEAS-2B cells Environmental toxicology, 2014; 29(11): 1292-300.
Shinkai Yasuhiro, Iwamoto Noriko, Miura Takashi, Ishii Takeshi, Cho Arthur K, Kumagai Yoshito   Redox cycling of 1,2-naphthoquinone by thioredoxin1 through Cys32 and Cys35 causes inhibition of its catalytic activity and activation of ASK1/p38 signaling Chemical research in toxicology, 2012; 25(6): 1222-30.
Kumagai Yoshito, Shinkai Yasuhiro, Miura Takashi, Cho Arthur K   The chemical biology of naphthoquinones and its environmental implications Annual review of pharmacology and toxicology, 2012; 52: 221-47.
Miura Takashi, Shinkai Yasuhiro, Hirose Reiko, Iwamoto Noriko, Cho Arthur K, Kumagai Yoshito   Glyceraldehyde-3-phosphate dehydrogenase as a quinone reductase in the suppression of 1,2-naphthoquinone protein adduct formation Free radical biology & medicine, 2011; 51(11): 2082-9.
Miura Takashi, Kakehashi Hidenao, Shinkai Yasuhiro, Egara Yuko, Hirose Reiko, Cho Arthur K, Kumagai Yoshito   GSH-mediated S-transarylation of a quinone glyceraldehyde-3-phosphate dehydrogenase conjugate Chemical research in toxicology, 2011; 24(11): 1836-44.
Miura Takashi, Shinkai Yasuhiro, Jiang Hai-Yan, Iwamoto Noriko, Sumi Daigo, Taguchi Keiko, Yamamoto Masayuki, Jinno Hideto, Tanaka-Kagawa Toshiko, Cho Arthur K, Kumagai Yoshito   Initial response and cellular protection through the Keap1/Nrf2 system during the exposure of primary mouse hepatocytes to 1,2-naphthoquinone Chemical research in toxicology, 2011; 24(4): 559-67.
Eiguren-Fernandez Arantzazu, Shinyashiki Masaru, Schmitz Debra A, DiStefano Emma, Hinds William, Kumagai Yoshito, Cho Arthur K, Froines John R   Redox and electrophilic properties of vapor- and particle-phase components of ambient aerosols Environmental research, 2010; 110(3): 207-12.
DiStefano Emma, Eiguren-Fernandez Arantzazu, Delfino Ralph J, Sioutas Constantinos, Froines John R, Cho Arthur K   Determination of metal-based hydroxyl radical generating capacity of ambient and diesel exhaust particles Inhalation toxicology, 2009; 21(9): 731-8.
Biswas Subhasis, Verma Vishal, Schauer James J, Cassee Flemming R, Cho Arthur K, Sioutas Constantinos   Oxidative potential of semi-volatile and non volatile particulate matter (PM) from heavy-duty vehicles retrofitted with emission control technologies Environmental science & technology, 2009; 43(10): 3905-12.
Shinyashiki Masaru, Eiguren-Fernandez Arantza, Schmitz Debra A, Di Stefano Emma, Li Ning, Linak William P, Cho Seung-Hyun, Froines John R, Cho Arthur K   Electrophilic and redox properties of diesel exhaust particles Environmental research, 2009; 109(3): 239-44.
Melega William P, Jorgensen Matthew J, Laćan Goran, Way Baldwin M, Pham Jamie, Morton Grenvill, Cho Arthur K, Fairbanks Lynn A   Long-term methamphetamine administration in the vervet monkey models aspects of a human exposure: brain neurotoxicity and behavioral profiles Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2008; 33(6): 1441-52.
Taguchi Keiko, Shimada Megumi, Fujii Sayako, Sumi Daigo, Pan Xiaoqing, Yamano Shigeru, Nishiyama Takahito, Hiratsuka Akira, Yamamoto Masayuki, Cho Arthur K, Froines John R, Kumagai Yoshito   Redox cycling of 9,10-phenanthraquinone to cause oxidative stress is terminated through its monoglucuronide conjugation in human pulmonary epithelial A549 cells Free radical biology & medicine, 2008; 44(8): 1645-55.
Iwamoto Noriko, Sumi Daigo, Ishii Takeshi, Uchida Koji, Cho Arthur K, Froines John R, Kumagai Yoshito   Chemical knockdown of protein-tyrosine phosphatase 1B by 1,2-naphthoquinone through covalent modification causes persistent transactivation of epidermal growth factor receptor The Journal of biological chemistry, 2007; 282(46): 33396-404.
Taguchi Keiko, Fujii Sayako, Yamano Shigeru, Cho Arthur K, Kamisuki Shinji, Nakai Yumi, Sugawara Fumio, Froines John R, Kumagai Yoshito   An approach to evaluate two-electron reduction of 9,10-phenanthraquinone and redox activity of the hydroquinone associated with oxidative stress Free radical biology & medicine, 2007; 43(5): 789-99.
Inoue Ken-Ichiro, Takano Hirohisa, Ichinose Takamichi, Tomura Shigeo, Yanagisawa Rie, Sakurai Miho, Sumi Daigo, Cho Arthur K, Hiyoshi Kyoko, Kumagai Yoshito   Effects of naphthoquinone on airway responsiveness in the presence or absence of antigen in mice Archives of toxicology, 2007; 81(8): 575-81.
Ntziachristos Leonidas, Froines John R, Cho Arthur K, Sioutas Constantinos   Relationship between redox activity and chemical speciation of size-fractionated particulate matter Particle and fibre toxicology, 2007; 4(8): 5.
Melega William P, Cho Arthur K, Harvey Dennis, Laćan Goran   Methamphetamine blood concentrations in human abusers: application to pharmacokinetic modeling Synapse (New York, N.Y.), 2007; 61(4): 216-20.
O'Neil Meghan L, Kuczenski Ronald, Segal David S, Cho Arthur K, Lacan Goran, Melega William P   Escalating dose pretreatment induces pharmacodynamic and not pharmacokinetic tolerance to a subsequent high-dose methamphetamine binge Synapse (New York, N.Y.), 2006; 60(6): 465-73.
Kikuno Shota, Taguchi Keiko, Iwamoto Noriko, Yamano Shigeru, Cho Arthur K, Froines John R, Kumagai Yoshito   1,2-Naphthoquinone activates vanilloid receptor 1 through increased protein tyrosine phosphorylation, leading to contraction of guinea pig trachea Toxicology and applied pharmacology, 2006; 210(1-2): 47-54.
Hiyoshi Kyoko, Takano Hirohisa, Inoue Ken-ichiro, Ichinose Takamichi, Yanagisawa Rie, Tomura Shigeo, Cho Arthur K, Froines John R, Kumagai Yoshito   Effects of a single intratracheal administration of phenanthraquinone on murine lung Journal of applied toxicology : JAT, 2005; 25(1): 47-51.
Kleinman Michael T, Hamade Ali, Meacher Dianne, Oldham Michael, Sioutas Constantinos, Chakrabarti Bhabesh, Stram Dan, Froines John R, Cho Arthur K   Inhalation of concentrated ambient particulate matter near a heavily trafficked road stimulates antigen-induced airway responses in mice Journal of the Air & Waste Management Association (1995), 2005; 55(9): 1277-88.
Cho Arthur K, Sioutas Constantinos, Miguel Antonio H, Kumagai Yoshito, Schmitz Debra A, Singh Manisha, Eiguren-Fernandez Arantza, Froines John R   Redox activity of airborne particulate matter at different sites in the Los Angeles Basin Environmental research, 2005; 99(1): 40-7.
Segal David S, Kuczenski Ronald, O'Neil Meghan L, Melega William P, Cho Arthur K   Prolonged exposure of rats to intravenous methamphetamine: behavioral and neurochemical characterization Psychopharmacology, 2005; 180(3): 501-12.
Rodriguez Chester E, Fukuto Jon M, Taguchi Keiko, Froines John, Cho Arthur K   The interactions of 9,10-phenanthrenequinone with glyceraldehyde-3-phosphate dehydrogenase (GAPDH), a potential site for toxic actions Chemico-biological interactions, 2005; 155(1-2): 97-110.
Rodriguez Chester E, Shinyashiki Masaru, Froines John, Yu Rong Chun, Fukuto Jon M, Cho Arthur K   An examination of quinone toxicity using the yeast Saccharomyces cerevisiae model system Toxicology, 2004; 201(1-3): 185-96.
Pan Chuan-Ju G, Schmitz Debra A, Cho Arthur K, Froines John, Fukuto Jon M   Inherent redox properties of diesel exhaust particles: catalysis of the generation of reactive oxygen species by biological reductants Toxicological sciences : an official journal of the Society of Toxicology, 2004; 81(1): 225-32.
Li Ning, Alam Jawed, Venkatesan M Indira, Eiguren-Fernandez Arantza, Schmitz Debra, Di Stefano Emma, Slaughter Ndaisha, Killeen Erin, Wang Xiaorong, Huang Aaron, Wang Meiying, Miguel Antonio H, Cho Arthur, Sioutas Constantinos, Nel Andre E   Nrf2 is a key transcription factor that regulates antioxidant defense in macrophages and epithelial cells: protecting against the proinflammatory and oxidizing effects of diesel exhaust chemicals Journal of immunology (Baltimore, Md. : 1950), 2004; 173(5): 3467-81.
Segal David S, Kuczenski Ronald, O'Neil Meghan L, Melega William P, Cho Arthur K   Escalating dose methamphetamine pretreatment alters the behavioral and neurochemical profiles associated with exposure to a high-dose methamphetamine binge Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2003; 28(10): 1730-40.
Segal DS, Kuczenski R, O'Neil ML, Melega WP and Cho AK   Escalating Dose Methamphetamine Pretreatment Alters the Behavioral and Neurochemical Profiles Associated with Exposure to a High-Dose Methamphetamine Binge, Neuropsychopharmacology , 2003; 10: 1730-1740.
Li Ning, Sioutas Constantinos, Cho Arthur, Schmitz Debra, Misra Chandan, Sempf Joan, Wang Meiying, Oberley Terry, Froines John, Nel Andre   Ultrafine particulate pollutants induce oxidative stress and mitochondrial damage Environmental health perspectives, 2003; 111(4): 455-60.
Li N, Sioutas C, Cho A, Schmitz D, Misra C, Sempf J, Wang M, Oberley T, Froines J, Nel A   Ultrafine particulate pollutants induce oxidative stress and mitochondrial damage Environmental health perspectives. , 2003; 111(4): 455-60.
Cho AK, Melega WP   Patterns of methamphetamine abuse and their consequences Journal of addictive diseases : the official journal of the ASAM, American Society of Addiction Medicine. , 2002; 21(1): 21-34.
Cho AK, Melega WP   Patterns of methamphetamine abuse and their consequences Journal of addictive diseases : the official journal of the ASAM, American Society of Addiction Medicine. , 2002; 21(1): 21-34.
Cho AK, Melega WP   Patterns of methamphetamine abuse and their consequences Journal of addictive diseases : the official journal of the ASAM, American Society of Addiction Medicine. , 2002; 21(1): 21-34.
Cho AK, Melega WP   Patterns of methamphetamine abuse and their consequences Journal of addictive diseases : the official journal of the ASAM, American Society of Addiction Medicine. , 2002; 21(1): 21-34.
Cho Arthur K, Melega William P   Patterns of methamphetamine abuse and their consequences Journal of addictive diseases, 2002; 21(1): 21-34.
Ost TW, Munro AW, Mowat CG, Taylor PR, Pesseguiero A, Fulco AJ, Cho AK, Cheesman MA, Walkinshaw MD, Chapman SK   Structural and spectroscopic analysis of the F393H mutant of flavocytochrome P450 BM3 Biochemistry. , 2001; 40(45): 13430-8.
Narimatsu S, Arai T, Masubuchi Y, Horie T, Hosokawa M, Ueno K, Kataoka H, Yamamoto S, Ishikawa T, Cho AK   Inactivation of rat cytochrome P450 2D enzyme by a further metabolite of 4-hydroxypropranolol, the major and active metabolite of propranolol, Biol Pharm Bull , 2001; 24: 988-94.
Cho AK, Melega WP, Kuczenski R, Segal DS   Relevance of pharmacokinetic parameters in animal models of methamphetamine abuse Synapse (New York, N.Y.) , 2001; 39(2): 161-6.
Cho AK, Melega WP, Kuczenski R, Segal DS, Schmitz DA   Caudate-putamen dopamine and stereotype response profiles after intravenous and subcutaneous amphetamine, Synapse, 1999; 31: 125-133.
Cho AK, Naraimatsu S, Kumagai Y   Metabolism of drugs of abuse by cytochromes P450, Addiction Biology, 1999; (in press): .
Melega WP, Cho AK, Schmitz D, Kuczenski R, Segal DS   l-methamphetamine pharmacokinetics and pharmacodynamics for assessment of in vivo deprenyl-derived l-methamphetamine The Journal of pharmacology and experimental therapeutics. , 1999; 288(2): 752-8.
Wang MY, Sheu BJ, Berger TW, Young WC, Cho AK   Architecture and design of 1-D enhanced cellular neural network processors for signal detection, Analog Integrated Circuits and Signal Processing , 1998; 15: 277-290.
Lin LY, Di Stefano EW, Schmitz DA, Hsu L, Ellis SW, Lennard MS, Tucker GT, Cho AK   Oxidation of methamphetamine and methylenedioxymethamphetamine by CYP2D6 Drug metabolism and disposition: the biological fate of chemicals. , 1997; 25(9): 1059-64.
Kuczenski R, Melega WP, Cho AK, Segal DS   Extracellular dopamine and amphetamine after systemic amphetamine administration: comparison to the behavioral response The Journal of pharmacology and experimental therapeutics. , 1997; 282(2): 591-6.
Narimatsu S, Arai T, Watanabe T, Masubuchi Y, Horie T, Suzuki T, Ishikawa T, Tsutsui M, Kumagai Y, Cho AK   Covalent binding of a reactive metabolite derived from propranolol and its active metabolite 4-hydroxypropranolol to hepatic microsomal proteins of the rat Chemical research in toxicology. , 1997; 10(3): 289-95.
Yamada H, Shiiyama S, Soejima-Ohkuma T, Honda S, Kumagai Y, Cho AK, Oguri K, Yoshimura H   Deamination of amphetamines by cytochromes P450: studies on substrate specificity and regioselectivity with microsomes and purified CYP2C subfamily isozymes The Journal of toxicological sciences. , 1997; 22(1): 65-73.
Chu T, Kumagai Y, DiStefano EW, Cho AK   Disposition of methylenedioxymethamphetamine and three metabolites in the brains of different rat strains and their possible roles in acute serotonin depiction, Biochem Pharmacol, 1996; 51: 789-796.
Lin LY, Fujimoto M, Distefano EW, Schmitz DA, Jayasinghe A, Cho AK   Selective mechanism-based inactivation of rat CYP2D by 4-allyloxymethamphetamine The Journal of pharmacology and experimental therapeutics. , 1996; 277(2): 595-603.

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